The Sky Poison Pearl (a.k.a Heavenly Poison Pearl) is one of the Seven Heavenly Profound Treasures with its rank being fifth. The Sky Poison Pearl's capabilities are centered around poison, medicine, purification and space. Its current owner is Yun Che and it has, due to the Mirror of Samsara, completely merged with Yun Che's left hand.
- Yun Che - Medical side currently merged with his left hand because of the Mirror of Samsara - Poison side currently merged with his right hand thanks to Yun Gu who had the other side.
- Yun Gu - How or who he got it from is unknown. He gave it to Yun Che before dying in the previous timeline.
- Evil God - Obtained it before the end of the Primordial Era.
- Heavenly Calamity Devil Emperor - First owner of the Sky Poison Pearl.
- Complete detoxification of any poison - How fast a poison will be detoxified depends on how potent it is.
- Helps with the opening of the Profound Entrances.
- Infinite inner storage space.
- Locate rare medical plants/herbs that is nearby.
- Perfect refining of medicinal ingredients.
- Poison. Its poison is called as Heaven Wounding Thought Severing Poison.
- Keeping alcohol inside to avoid drinking it 
— Yun Gu about the Sky Poison Pearl's poison
- Yun Che killed over 7.7 million people in a day with its poisonous AOE. [ch 54]
- If the Sky Poison Pearl is used with the Evil Infant’s Wheel of Myriad Calamities, it will give birth to the World Destroying Poison: Life Extinguishing Myriad Calamities.
- Even though it is said that its poison is heaven defying, for unknown reasons it can kill at most, Tyrant Profound Realm cultivators.