The Sky Poison Pearl is one of the Seven Heavenly Profound Treasures with its rank being fifth. The Sky Poison Pearl's capabilities are centered around poison, medicine, purification and space. Its current owner is Yun Che and it has, due to the Mirror of Samsara, completely merged with Yun Che's left hand.
- Medical Saint - how or who he got it from is unknown; upon his death he gave it Yun Che
- Complete detoxification of any poison - How fast a poison will be detoxified depends on how potent it is.
- Helps with the opening of the Profound Entrances
- Infinite inner storage space
- Locate rare medical plants/herbs that is nearby
- Perfect refining of medicinal ingredients
- Its poison was used beyond exhaustion resulting in it not being able to recover.
- Keeping alcohol inside to avoid drinking it 
- Yun Che killed over 7 million people with its poisonous AOE.